Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists,antagonists and derivatives |
| |
| Authors: | Gustavo Provensi Alessio Nocentini Maria Beatrice Passani Patrizio Blandina Claudiu T. Supuran |
| |
| Affiliation: | aDepartment of NEUROFARBA, University of Florence, Section of Pharmacology and Toxicology, Firenze, Italy;bDepartment of Health Science, University of Florence, Section of Clinical Pharmacology and Oncology, Firenze, Italy |
| |
| Abstract: | Carbonic anhydrases (CAs, EC 4.2.1.1) activators were shown to be involved in memory enhancement and learning in animal models of cognition. Here we investigated the CA activating effects of a large series of histamine based compounds, including histamine receptors (H1R – H4R) agonists, antagonists and other derivatives of this autacoid. CA activators may be thus useful for improving cognition as well as in diverse therapeutic areas (phobias, obsessive-compulsive disorder, generalised anxiety, post-traumatic stress disorders), for which activation of this enzyme was recently shown to be involved. |
| |
| Keywords: | Carbonic anhydrase activators cognition-related disorders histamine receptors agonists/antagonists |
|
|
