The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge |
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| Authors: | Hua Yu Changwan Lu Ming T Tan Kamal D Moudgil |
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| Institution: | (1) Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 West Baltimore Street, HSF-1, Suite 380, Baltimore, MD 21201, USA;(2) Department of Medicine, University of Maryland School of Medicine, 685 West Baltimore Street, MSTF-314, Baltimore, MD 21201, USA;(3) Division of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, 685 West Baltimore Street, MSTF-261, Baltimore, MD 21201, USA;(4) OrgDivision>Division of Rheumatology, Department of Medicine, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA |
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| Abstract: | Introduction Autoimmune inflammation is a characteristic feature of rheumatoid arthritis (RA) and other autoimmune diseases. In the natural
course of human autoimmune diseases, it is rather difficult to pinpoint the precise timing of the initial event that triggers
the cascade of pathogenic events that later culminate into clinically overt disease. Therefore, it is a challenge to examine
the early preclinical events in these disorders. Animal models are an invaluable resource in this regard. Furthermore, considering
the complex nature of the pathogenic immune events in arthritis, microarray analysis offers a versatile tool to define the
dynamic patterns of gene expression during the disease course. |
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| Keywords: | adjuvant arthritis gene expression heat shock proteins immune tolerance microarray analysis |
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