Antifungal rosane diterpenes and other constituents of Hugonia castaneifolia |
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Authors: | Baraza Lilechi D Joseph Cosam C Munissi Joan J E Nkunya Mayunga H H Arnold Norbert Porzel Andrea Wessjohann Ludger |
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Institution: | Department of Chemistry, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania. |
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Abstract: | The rosane diterpenoids hugorosenone 3beta-hydroxyrosa-1(10),15-dien-2-one], 18-hydroxyhugorosenone and 18-hydroxy-3-deoxyhugorosenone, and 12-hydroxy-13-methylpodocarpa-8,11,13-trien-3-one were isolated as antifungal constituents of H. castaneifolia Engl. root bark, together with the previously reported di-podocarpanoids hugonone A and hugonone B that were weakly active, and 1(10),15-rosadiene-2beta,3beta-diol (hugorosenol), 4alpha-methoxyhimachal-10-en-5beta-ol (hugonianene B) and 2-hydroxyhenpentacont-2-enal, and the known compounds tetracosyl-(E)-ferrulate and caryophyllene oxide, all of which were inactive. Hugorosenone also exhibited activity against Anopheles gambiae mosquito larvae. Structural determination was achieved based on spectroscopic data. |
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Keywords: | Hugonia castaneifolia Linaceae Antifungal Larvicidal Rosane diterpenoids Himachalenoid 2-Hydroxyhenpentacont-2-enal |
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