Molecular requirements for the adhesion and spreading of hamster fibroblasts |
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Authors: | R. C. Hughes S. D. J. Pena J. Clark R. R. Dourmashkin |
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Abstract: | Hamster plasma fibronectin adsorbs rapidly to a plastic surface to form a monolayer that promotes attachment and spreading of baby hamster kidney (BHK) fibroblasts. Maximal spreading requires a minimum surface density of about 1.8 × 1010 fibronectin molecules/cm2 indicating a maximum of 45 000 contacts between a well-spread cell and the adsorbed fibronectin lattice. Surfaces coated with other antibodies or lectins reactive with the BHK cell surface also promote rapid cell flattening. |
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