Synthesis of substituted indole derivatives as a new class of antimalarial agents |
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| Authors: | Agarwal Anu Srivastava Kumkum Puri S K Chauhan Prem M S |
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| Affiliation: | Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India. |
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| Abstract: | A series of substituted indole derivatives were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 24 compounds synthesized six compounds have shown MIC of 1 microg/mL. These compounds are in vitro several folds more active than pyrimethamine. |
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