Genetic and molecular mapping of the Hmt region of mouse. |
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Authors: | S Richards M Bucan K Brorson M C Kiefer S W Hunt rd H Lehrach and K F Lindahl |
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Institution: | Howard Hughes Medical Institute, Dallas, TX. |
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Abstract: | We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies between a recombinational breakpoint distal to Tla and another proximal to Tpx-1, thus including Pgk-2. A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4. Both lie proximal to Pgk-2, within the distal inversion in t-haplotypes. The presence of several other MHC class I genes in the Hmt region is predicted from analysis of the recombinants that define the region. |
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