| 趋化因子共受体在1型人免疫缺陷病毒感染中的作用 |
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| 引用本文： | 孙利,张久聪,孙永涛.趋化因子共受体在1型人免疫缺陷病毒感染中的作用[J].生物技术通讯,2010,21(1):90-93. |
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| 作者姓名： | 孙利 张久聪 孙永涛 |
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| 作者单位： | 第四军医大学,唐都医院传染病科,陕西,西安,710038 |
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| 摘 要： | 1型人免疫缺陷病毒(HIV-1)感染靶细胞是一个包含病毒膜蛋白和细胞膜受体相互作用的多极化过程,CCR5和CXCR4作为趋化因子受体参与这一过程,并且是M嗜性和T嗜性HIV-1感染的重要共受体。文章总结了作者在HIV-1共受体方面的工作,对趋化因子受体作为新的治疗HIV-1感染的工具的最新进展做了简要综述。
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| 关 键 词： | 趋化因子 共受体 CXCR4 CCR5 人免疫缺陷病毒 |
Effect of Chemokine Coreceptor on HIV-1 Infection |
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| SUN Li,ZHANG Jiu-Cong,SUN Yong-Tao.Effect of Chemokine Coreceptor on HIV-1 Infection[J].Letters in Biotechnology,2010,21(1):90-93. |
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| Authors: | SUN Li ZHANG Jiu-Cong SUN Yong-Tao |
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| Institution: | SUN Li,ZHANG Jiu-Cong,SUN Yong-Tao PLA Center for the Treatment of Infectious Diseases,Tangdu Hospital,Fourth Military Medical University,Xi\'an 710038,China |
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| Abstract: | Human immunodeficiency virus type 1(HIV-1)entry into target cells is a multi-step process involving the interaction of viral envelope proteins with cell surface receptors.CCR5 and CXCR4 are receptors that bind several natural chemokines and are also major coreceptors for M-tropic and T-tropic HIV-1 infection.The current paper summarized our HIV-1 coreceptor related work and recent advance of chemokine receptor as a new tool in the treatment of HIV-1 infection. |
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| Keywords: | CXCR4 CCR5 |
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