Coenzyme dissociation, a possible determinant of short half-life of inducible enzymes in mammalian liver

Corticosteroid inducible, rapidly turning-over ($\text{t}\text{1}\text{2}\text{= 12}$ min to 3 hrs) enzymes of rat liver cytosol are complex enzymes with dissociable coenzymes. Enzymatic activity can be used to measure the relative rate of coenzyme dissociation. A comparison of rapidly inducible compared to relatively uninducible complex enzymes shows that the relative rate of coenzyme dissociation aligns with the shortness of the $\text{t}\text{1}\text{2}$ of the enzyme suggesting that coenzyme dissociation may be a limiting step in the degradation process of these enzymes.