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Differentiation impairs low pH-induced Ca2+ signaling and ERK phosphorylation in granule precursor tumour cells
Authors:Wan-Chen Huang  Pawel Swietach  Richard D. Vaughan-Jones  Maike D. Glitsch
Affiliation:1. Department of Physiology, Anatomy and Genetics, Sherrington Building, Oxford University, Parks Road, Oxford OX1 3PT, United Kingdom;2. Burdon Sanderson Cardiac Science Centre, Oxford University, Parks Road, Oxford OX1 3PT, United Kingdom;1. Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy;2. Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Amadeo 42, 20133 Milan, Italy;3. Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B 07100 Sassari, Italy;4. Histology and Molecular Diagnostic, University Hospital Careggi, Viale G.B. Morgagni 85, 50134 Florence, Italy;5. Center for Research, Transfer and High Education ‘Study at Molecular and Clinical Level of Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development on Novel Therapies’, Italy;1. Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, United States;2. University of Illinois Cancer Center, Chicago, IL, 60612, United States;1. Ontario Cancer Institute and Princess Margaret Cancer Center (University Health Network), Toronto, Ontario, Canada;2. Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada;3. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada;4. Department of Pathology and Laboratory Medicine, Toronto General Hospital (University Health Network), Toronto, Ontario, Canada;1. Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY, USA;2. Department of Cancer Biology, Cleveland Clinic, Cleveland, OH, USA;3. Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA;4. Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA;5. Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA;6. Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, USA;7. Department of Urology, Cleveland Clinic, Cleveland, OH, USA;8. Department of Hematology/Medical Oncology, Cleveland Clinic, Cleveland, OH, USA
Abstract:
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