首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Recent progress on STIM1 domains controlling Orai activation
Authors:R Schindl  M Muik  M Fahrner  I Derler  R Fritsch  J Bergsmann  C Romanin
Institution:1. Faculty of Medical Technology, Rangsit University, Phathum Thani, Thailand;2. Division of Molecular Medicine, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;3. Department of Anatomy, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;4. Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;5. Medical Biotechnology Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Thailand;1. Koç University, Advanced Materials Group (AMG), Department of Mechanical Engineering, Sar?yer, 34450 ?stanbul, Turkey;2. California Polytechnic State University, Materials Engineering Department, San Luis Obispo, CA 93407, USA;3. Koç University, School of Medicine, Sar?yer, 34450 ?stanbul, Turkey;4. Leibniz Universität Hannover, Institut für Werkstoffkunde (Materials Science), An der Universität 2, 30823 Garbsen, Germany;5. Koç University Surface Science and Technology Center (KUYTAM), Sar?yer, 34450 ?stanbul, Turkey
Abstract:Ca2+ entry in non-excitable cells is mainly carried by store-operated channels among which the CRAC channel is best characterized. Its two limiting molecular components are represented by the Ca2+ sensor protein STIM1 located in the endoplasmic reticulum and Orai1 in the plasma membrane. STIM1 senses a decrease of the Ca2+ content in internal stores and triggers its accumulation into puncta like structures resulting in coupling to as well as activation of Orai1 channels. The STIM1–Orai coupling process is determined by an interaction via their C-termini. This review highlights recent developments on domains particularly within the cytosolic part of STIM1 that govern this interaction.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号