Bibliography |
| |
| Authors: | Thales R. Cipriani Caroline G. Mellinger Lauro M. de Souza Cristiane H. Baggio Cristina S. Freitas Maria Consuelo A. Marques Philip A.J. Gorin Guilherme L. Sassaki Marcello Iacomini |
| |
| Affiliation: | 1. Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, CEP 81531-980, CP 19046, Curitiba, PR, Brazil;2. Departamento de Farmacologia, Universidade Federal do Paraná, CEP 81531-980, CP 19031, Curitiba, PR, Brazil |
| |
| Abstract: | Maytenus ilicifolia is one of frequently used medicinal plants in Brazil. Its leaves are used in homemade and industrial medicines for effective treatment of stomach ulcers. A polygalacturonic acid (PGA) was obtained from its leaves by aqueous extraction, followed by fractionation via a freezing–thawing process and Fehling precipitation. Methylation analysis and 13C NMR spectroscopy showed PGA to consist of (1 → 4)-linked α-d-GalpA repeating units. It significantly inhibited ethanol-induced gastric lesions in rats, with an ED50 of 103 mg/kg, suggesting that it has a protective anti-ulcer effect. This polysaccharide may thus play an important role in the anti-ulcer effect of M. ilicifolia. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
