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Biosynthesis of riboflavin 6,7-dimethyl-8-ribityllumazine 5′-phosphate is not a substrate for riboflavin synthase |
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| Authors: | G Harzer H Rokos MK Otto A Bacher S Gishla S Ghisla |
| Institution: | 1. Fachbereich Biologie, Universität Konstanz, D-7750 Konstanz, F.G.R.;2. Institut für Mikrobiologie, Universität Hohenheim, D-7000 Stuttgart 70 G.F.R. |
| Abstract: | Phosphotransferase from carrot is shown to catalyze the phosphorylation of 6,7-dimethyl-8-ribityllumazine specifically at position 5′ of the ribityl side chain. The lumazine 5′-phosphate is neither a substrate nor an inhibitor of riboflavin synthase from Bacillus subtilis and Escherichia coli. It follows that the obligatory product of riboflavin synthase is riboflavin and not FMN. |
| Keywords: | Correspondence should be addressed to: Dr A Bachter Institut für Mikrobiologie Universität Hohenheim 7000 Suttgart 70 German Federal Republic |
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