Patterns of gene expression and the cellular origins of human leukaemias期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Patterns of gene expression and the cellular origins of human leukaemias

Authors:	Melvin Greaves

Affiliation:	Membrane Immunology Laboratory, Imperical Cancer Research Fund, London, U.K.

Abstract:

Keywords:	ALL acute lymphoblastic leukaemia AUL acute undifferentiated leukaemia AML acute mycloblastic leukaemia CML chronic myeloid leukaemia CML be chronic myeloid leukaemia in blast crisis CLL chronic lymphocytic leukaemia The Philadelphia chromosome T thymus derived cell B Bursa-equivalent derived cell Thy-ALL ALL with a thymic phenotype c-ALL ALL with the major or common phenotylpe (ALL antigen positive) B-ALL ALL with a B cell phenotype Hex I Hexosaminidase intermediate peak isoenzyme Ig Immunoglobulin SmIg surface membrane immunoglobulin HuTLA human T lymphocyte antigen(s) HuMA human myeloid-monocytic antigen(s) Ia Membrane antigens coded for in rodents by genes of the H-2 (in mice) linked I (immune response gene) region/loci. Called Ia or lsIa-likers in man by analogy. Antisera to these human antigens (which are D locus coded) are referred to as anti-lsIars or anti-p. 28,33 (the B cell glycoproteins commonly used to produce the reagents) HLA major histocompatibility locus in man (on chromosome 6) coding for cell surface proteins LD lymphocyte defined (mixed lymphocyte reaction) HLA locus in man D a genetic region of HLA (close to or identical with LD), the cell surface products of which are detected serologically Gm antigenic determinants with allelic polymorphism on human IgG molecules E erythrocytes (sheep) rosettes FACS flourescence activated cell sorter EBV Epstein-Barr virus LETS large external transformation sensitive MHC major histocompatibility complex FOCMA feline oncornavirus membrane antigen TSSA timour specific transplantation antigen LYDMA lymphocyte defined membrane antigen of Epstien-Barr virus transformed B lymlphocytes
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