Uridine kinase in embryonic rat liver. Modulation of enzyme activity by 5-azacytidine |
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| Authors: | J Vesely A ?ihák |
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| Institution: | Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Flemingovo 2, Prague 6, Czechoslovakia |
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| Abstract: | Uridine kinase activity in rat liver decreases during embryonic and postnatal development. Administration of 5-azacytidine enhances liver uridine kinase activity in adult rats, but depresses it in embryos. The liver enzymes from the foetus and the adult are precipitated at different (NH(4))(2)SO(4) concentrations although they are eluted at about the same position on chromatography on a column of Sepharose 6B. |
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