Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention. |
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| Authors: | K Midorikawa M Murata S Oikawa Y Hiraku S Kawanishi |
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| Affiliation: | Department of Hygiene, Mie University School of Medicine, Mie, 514-8507, Japan. |
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| Abstract: | Phytic acid (myo-inositol hexaphosphate) is one of the most promising cancer chemopreventive agents. We investigated the mechanism by which phytic acid expresses preventive action to cancer. Phytic acid inhibited the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in cultured cells treated with an H2O2-generating system, although it did not scavenge H2O2. Site-specific DNA damage by H2O2 and Cu(II) at GG and GGG sequences was inhibited by phytic acid, but not by myo-inositol. Phytic acid alone did not cause DNA damage and thus, it should not act as a prooxidant. We conclude that phytic acid acts as an antioxidant to inhibit the generation of reactive oxygen species from H2O2 by chelating metals, resulting in chemoprevention of cancer. |
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