Effects of zinc deficiency and supplementation on plasma leptin levels in rats |
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Authors: | Abdulkerim Kasim Baltaci Rasim Mogulkoc Ihsan Halifeoglu |
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Affiliation: | (1) Department of Physiology, Meram Medical School, Selcuk University, Konya, Turkey;(2) Department of Biochemistry, Medical School, Firat University, Elazig, Turkey |
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Abstract: | The effects of zinc deficiency and supplementation on plasma leptin levels were studied in Sprague-Dawley rats. After 6 wk on a zinc-deficient diet containing 0.65 ppm Zn/g, the mean body weight was significantly lower than that of normal or zinc-supplemented rats, which showed no difference among them. The plasma leptin and zinc levels were lowest in zinc-deficient animals and highest in those that received a normal diet and daily intraperitioneal injections of 3 mg Zn/kg. These results indicate that zinc deficiency leads to a significant inhibition in plasma leptin levels, whereas zinc supplementation significantly increases plasma leptin. |
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Keywords: | Zinc deficiency and supplementation leptin, rat |
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