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Design, synthesis, and evaluation of proline based melanocortin receptor ligands |
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| Authors: | Tian Xinrong Field Timothy Mazur Adam W Ebetino Frank H Wos John A Crossdoersen Doreen Pinney Beth B Sheldon Russell J |
| Institution: | Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA. tian.x@pg.com |
| Abstract: | A series of proline based melanocortin ligands has been developed on the basis of initial piperazine leads by using a more conformationally rigid scaffold. A number of these novel ligands showed significant binding affinity for MC3 and MC4 receptors. |
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