| Targeting exported substrates to the Yersinia TTSS: different functions for different signals? |
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| 作者姓名： | Lloyd SA Forsberg A Wolf-Watz H Francis MS |
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| 摘 要： |
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Targeting exported substrates to the Yersinia TTSS: different functions for different signals? |
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| Lloyd SA,Forsberg A,Wolf-Watz H,Francis MS.Targeting exported substrates to the Yersinia TTSS: different functions for different signals?[J].Trends in Microbiology,2001,9(8):367-371. |
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| Authors: | Lloyd S A Forsberg A Wolf-Watz H Francis M S |
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| Institution: | 1. Department of Veterinary Science, Unit of Food Hygiene, University of Parma, Via del Taglio 10, 43126 Parma, Italy;2. Istituto Zooprofilattico Sperimentale della Lombardia e dell''Emilia-Romagna, Sezione di Brescia, Via Bianchi, 9, 25124 Brescia, Italy;3. Department Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium;5. National Veterinary Service, Local Unit of Parma, Via Vasari 13/A, 43126 Parma, Italy;1. Department of Pharmacology and Toxicology, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany;2. Drug Discovery, Bayer AG, Aprather Weg 18a, Wuppertal 42113, Germany;1. Centre for Perioperative Optimisation, Department of Surgery, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark;2. Department of Clinical Microbiology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark |
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| Abstract: | Many Gram-negative pathogens utilize a type III secretion system (TTSS) to inject toxins into the cytosol of eukaryotic cells. Previous studies have indicated that exported substrates are targeted to the Yersinia TTSS via the coding regions of their 5' mRNA sequences, as well as by their cognate chaperones. However, recent results from our laboratory have challenged the role of mRNA targeting signals, as we have shown that the amino termini of exported substrates are crucial for type III secretion. Here, we discuss the nature of these amino-terminal secretion signals and propose a model for the secretion of exported substrates by amino-terminal and chaperone-mediated signals. In addition, we discuss the roles of chaperones as regulators of virulence gene expression and present models suggesting that such regulation can occur independently of the delivery of their substrates to the secretion apparatus. |
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