Netrin-1 in the developing enteric nervous system and colorectal cancer |
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Authors: | Suh Youn Ko Crispin R Dass Kulmira Nurgali |
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Affiliation: | School of Biomedical and Health Sciences, Victoria University, St Albans 3021, Australia. |
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Abstract: | Netrin-1 is a well-characterised chemoattractant involved in neuronal guidance in the developing enteric nervous system (ENS), but it is also a regulator of tumorigenesis. Two of its well-characterised receptors, deleted in colorectal cancer (DCC) and uncoordinated-5 homolog (UNC-5H), belong to a family of dependence receptors that transmit either pro- or anti-apoptosis signals depending on the availability of ligand, in this case netrin-1. This review summarises these two effects of netrin-1 and highlights the additional research needed information about to allow better utilisation of netrin-1 as a therapeutic target for axonal regeneration in the context of colorectal cancer. |
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