Armeniaspiroles, a new class of antibacterials: antibacterial activities and total synthesis of 5-chloro-Armeniaspirole A |
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Authors: | Cédric Couturier Armin Bauer Astrid Rey Cosima Schroif-Dufour Mark Broenstrup |
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Institution: | Sanofi Research & Development, TSU Infectious Disease, 195, route d'Espagne BP 13669 31036 Toulouse Cedex 1, France. Electronic address: cedric.couturier@sanofi.com. |
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Abstract: | Armeniaspiroles, a novel class of natural products isolated from Streptomyces armeniacus, are characterized by a novel spiro4.4]non-8-ene scaffold. Various derivatives of Armeniaspiroles could be obtained by halogenation, alkylation, addition/elimination or reductions. A total synthesis of the 5-chloro analog of Armeniaspirole A has been accomplished in a linear six-step sequence. 5-Chloro-Armeniaspirole A exhibits good activity against a range of multidrug-resistant, Gram-positive bacterial pathogens. |
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