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Paracentric inversion inv(11) (q21q23) in the Netherlands
Authors:K. Madan  M. H. E. C. Pieters  L. P. Kuyt  C. J. van Asperen  J. M. de Pater  A. J. H. Hamers  K. B. J. Gerssen-Schoorl  T. W. J. Hustinx  A. S. P. M. Breed  J. O. Van Hemel  D. F. C. M. Smeets
Affiliation:(1) Institute of Human Genetics, Free University, Postbus 7057, NL-1007 MB Amsterdam, The Netherlands;(2) Department of Genetics and Cell Biology, University of Limburg, Postbus 616, NL-6200 MD Maastricht, The Netherlands;(3) Institute of Human Genetics, University of Amsterdam, Meibergdreef 15, NL-1105 AZ Amsterdam, The Netherlands;(4) Clinical Genetics Centre, Postbus 18009, NL-3501 CA Utrecht, The Netherlands;(5) Regional Pathological Laboratory, Edo Bergsmalaan 1, NL-7512 AD Enschede, The Netherlands;(6) Institute of Human Genetics, Catholic University of Nijmegen, Geert Grooteplein Zuid 10, NL-6500 HB Nijmegen, The Netherlands;(7) Institute of Human Genetics, University of Groningen, Antonius Deusinglaan 4, NL-9713 AW Groningen, The Netherlands;(8) Department of Clinical Genetics, Dijkzigt Academic Hospital, Erasmus University, Postbus 1738, NL-3000 DR Rotterdam, The Netherlands;(9) Cytogenetics Laboratory, O Central Hall 13, Polikliniek building, Free University Hospital, Postbus 7057, NL-1007 MB Amsterdam, The Netherlands
Abstract:Summary We report the result of investigations from 20 families with 72 carriers of the paracentric inversion inv(11)(q21q23) in the Netherlands. There is no increase in the rate of spontaneous abortions among carriers of the inversion or their partners. Also, so far, there are no children with recombinant chromosomes arising from the inversion. It is doubtful whether prenatal diagnosis would be helpful to carriers of this inversion. The results of the genealogy study and geographical distribution are discussed; it is suggested that all the families have arisen from a single mutation.
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