| 线粒体DNA与DNA甲基化 |
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| 引用本文： | 刘振山,冯云,薛志刚,范国平.线粒体DNA与DNA甲基化[J].生物学杂志,2013(5):77-80. |
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| 作者姓名： | 刘振山 冯云 薛志刚 范国平 |
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| 作者单位： | [1]同济大学医学院千细胞研究中心,上海200092 [2]加州大学戴维格芬医学院人类遗传学教研室,美国洛杉矾90095 |
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| 基金项目： | 国家自然科学基金（项目编号：81271258）;科技部973基础研究计划（项目编号：2011CB965102,2011CB966204） |
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| 摘 要： | 线粒体是除细胞核之外唯一携带遗传物质的细胞器,其线粒体DNA（mitochondrial DNA,mtDNA）控制着线粒体一些最基本的性质,对细胞功能有着重要影响.DNA甲基化是调节基因表达的重要方式之一.研究表明mtDNA存在CpG位点的低甲基化,并且mtDNA基因的表达受核DNA（nuclear DNA,nDNA）及线粒体自身DNA甲基化的调控,mtDNA和nDNA协同作用参与机体代谢调节和疾病发生发展过程.就近年来mtDNA与DNA甲基化的关系作一综述.
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| 关 键 词： | 线粒体DNA DNA甲基化 5mC 5hmC |
The relationship between mitochondrial DNA and DNA methylation |
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| LIU Zhen-shan,FENG Yun,XUE Zhi-gang,FAN Guo-ping.The relationship between mitochondrial DNA and DNA methylation[J].Journal of Biology,2013(5):77-80. |
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| Authors: | LIU Zhen-shan FENG Yun XUE Zhi-gang FAN Guo-ping |
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| Institution: | 1. Stem Cell Research Center, Department of Regenerative Medicine, School of Medicine, Tongji University, Shanghai 200092, China; 2. Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA) |
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| Abstract: | Mitochondrion is the only organelle that carries DNA besides nucleus. It holds a central position between energy uptake and energy production. Mitochondrial dysfunction is a common cause of human diseases. Recently, a low level of DNA methylation was ob- served in mitochondrial DNA （mtDNA）. Because DNA methylation is an important epigenetic mechanism involved in gene regulation, it is proposed that expression of mitochondrial genes is regulated by methylation of mtDNA. This paper reviewed the recent progresses on DNA methylation in the mtDNA. |
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| Keywords: | mitochondrial DNA DNA methylation 5mC 5hmC |
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