Decreased brown adipose tissue thermogenic activity following a reduction in brain serotonin by intraventricular p-chlorophenylalanine |
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| Authors: | Nigel J Fuller Dorothy M Stirling Stephen Dunnett Gavin P Reynolds Margaret Ashwell |
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| Institution: | (1) MRC Dunn Nutrition Unit, Downhams Lane, Milton Road, CB4 1XJ Cambridge;(2) Department of Experimental Psychology, University of Cambridge, CB2 2EB Cambridge, UK;(3) Department of Pathology, University of Nottingham Medical School, Queen's Medical Centre, NG7 2UH Nottingham |
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| Abstract: | The effects of reducing brain serotonin (5-HT) levels by means of intracerebral-ventricular injections of the tryptophan antagonist p-chlorophenylalanine (PCPA) were investigated in male rats. Six days after the operation, PCPA-treated rats, either fedad libitum or pair-fed to the food intake of control rats, showed decreased thermogenic activity and capacity in their interscapular brown adipose tissue (BAT) and also increased fat storage in their white adipose tissue (WAT). These results indicate that serotonergic synapses might play a regulatory role in the sympathetic control of BAT thermogenesis and in the rate of WAT deposition (by an as yet unidentified mechanism), in addition to their well established role in controlling food intake. |
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| Keywords: | brown adipose tissue serotonin p-chlorophenylalanine thermogenesis |
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