Application of carboxylic-phosphinic mixed anhydrides in the fragment peptide synthesis of protected analogues of substance P. |
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Authors: | C Poulos P Pasalimaniotou A Manolopoulou T Tsegenidis |
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Institution: | Department of Chemistry, University of Patras, Greece. |
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Abstract: | Mixed carboxylic-phosphinic anhydrides derived from peptide acids and 1-oxo-1-chlorophospholane have been applied in the synthesis of the protected Leu11]-SP by the fragment coupling strategy. The yields from fragment couplings were ca. 75%, the products were of high purity while the conditions of formation and coupling of the corresponding mixed phosphinic anhydrides, for optimum yields, have been evaluated. |
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