Lack of Correspondence between the Amplitudes of Spontaneous Potentials and Unit Potentials evoked by Nerve Impulses at Regenerating Neuromuscular Junctions

IT is known from earlier studies of regeneration of neuromuscular synapses in the frog¹ that the nerve fibres return to the region of the original end-plate and that there is a time after the ending has re-established synaptic contact during which a nerve impulse fails to evoke transmitter release, even though spontaneous release occurs. Even after neuromuscular transmission is restored, the response latency is longer than usual and the nerve is more liable to presynaptic failure of propagation¹. This study is part of an attempt to examine in more detail the characteristics of transmitter release during this period.