Gamma-lactones alpha,beta- and beta,gamma-fused to carbocycles as novel antiproliferative drugs |
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| Authors: | León Leticia G Machín Rubén P Rodríguez Carmen M Ravelo José L Martín Víctor S Padrón José M |
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| Affiliation: | Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain. |
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| Abstract: | A set of gamma-lactones alpha,beta-fused and beta,gamma-fused to carbocycles have been synthesized and evaluated for their in vitro antiproliferative activities using the human cancer cell lines SW1573 (lung), T-47D (breast) and WiDr (colon). The compounds are obtained by intramolecular ring closing metathesis of the corresponding dienes. Active compounds exhibited GI(50) values in the range 8-18 microM. A structure-activity relationship is also discussed. |
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