Kinase array design, back to front: biaryl amides |
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Authors: | Baldwin Ian Bamborough Paul Haslam Claudine G Hunjan Suchete S Longstaff Tim Mooney Christopher J Patel Shila Quinn Jo Somers Don O |
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Institution: | GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK. |
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Abstract: | New kinase inhibitors can be found by synthesis of targeted arrays of compounds designed using system-based knowledge as well as through screening focused or diverse compounds. Most array strategies aim to add functionality to a fragment that binds in the purine subpocket of the ATP-site. Here, an alternative pharmacophore-guided array approach is described which set out to discover novel purine subpocket-binding groups. Results are shown for p38alpha and cFMS kinase, for which multiple distinct series with nanomolar potency were discovered. Some of the compounds showed potency in cell-based assays and good pharmacokinetic properties. |
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