Development of a bioassay for the antitumor activity of biological response modifiers of the reticuloendothelial stimulant class |
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| Authors: | J. W. Proctor Y. Yamamura N. R. DiLuzio P. W. A. Mansell J. Harnaha |
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| Affiliation: | (1) Allegheny Singer Research Corporation, Radiation Research Laboratories, Allegheny General Hospital, 15212 Pittsburgh, PA, USA;(2) Department of Physiology, Tulane University Medical School, 70112 New Orleans, LA, USA;(3) Comprehensive Cancer Center for the State of Florida, University of Miami School of Medicine, Jackson Memorial Medical Center, 33152 Miami, FL, USA |
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| Abstract: | Summary Following intravenous administration of various doses of DiLuzio glucan, Wellcome C. parvum, or BCG, the increase in clearance of intravenous 125IUdR-radiolabeled B16 tumor cells from the lung correlated with a subsequent reduction in the outgrowth of pulmonary tumor nodules. The ranges of values for tumor cell clearance were very much narrower for most groups of animals than the ranges obtained for the number of pulmonary tumor nodules in similar groups, allowing 2–3 times the definition of data with the former method. |
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