Metal-binding sites in proteins. |
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| Authors: | J A Tainer V A Roberts E D Getzoff |
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| Affiliation: | Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037. |
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| Abstract: | A dramatic increase in the number of solved metalloprotein structures and recent breakthroughs in structural analysis have provided a sufficiently detailed understanding of the structural chemistry of some metal-binding sites to allow successful design. As a result, metal-binding site design is now one of the most powerful and promising approaches for influencing protein folding, assembly, stability and catalysis. |
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