Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF |
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| Authors: | Noriko Esumi Marcia Budarf Lawrence Ciccarelli Beatrice Sellinger Christine A Kozak Graeme Wistow |
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| Institution: | (1) Section on Molecular Structure and Function, National Eye Institute, Building 6 Room 331, National Institutes of Health, Bethesda, Maryland 20892-2740, USA, US;(2) Dept. of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA, US;(3) The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104-4399, USA, US;(4) Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland 20892 USA, US |
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| Abstract: | Macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT) are small proteins, which are related both
by sequence and by in vitro enzyme activity. Here we show that the gene for DDT in human and mouse is identical in exon structure
to MIF. Both genes have two introns that are located at equivalent positions, relative to a twofold repeat in protein structure.
Although in similar positions, the introns are in different phases relative to the open reading frame. Other members of this
superfamily exist in nematodes and a plant, and a related gene in C. elegans shares an intron position with MIF and DDT. In addition to similarities in structure, the genes for DDT and MIF are closely
linked on human Chromosome (Chr) 22 and mouse Chr 10.
Received: 12 February 1998 / Accepted: 8 May 1998 |
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