Influence of L-lysine and zinc administration during exposure to lead or lead and ethanol in rats |
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Authors: | Sushil Kumar Tandon Surendra Singh Satgur Prasad Neeraj Mathur |
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Institution: | (1) Chemical Toxicology, Industrial Toxicology Research Centre, 226001 Lucknow, India |
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Abstract: | Influence of lysine and zinc administration on the lead-sensitive biochemical parameters and the accumulation of lead during
exposure to lead or lead and ethanol was investigated in rats. The lead exposure inhibited blood δ-aminolevulinic acid dehydratase
(ALAD) activity, increased blood zinc protoporphyrin (ZPP), urinary δ-aminolevulinic acid (ALA), serum glutamic oxalacetic
transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), blood and tissue lead levels, and decreased blood and hepatic
glutahione (GSH) contents. Some of these effects were enhanced on coexposure to ethanol. The simultaneous administration of
lysine and zinc reduced tissue accumulation of lead and most of the lead-induced biochemical alterations irrespective of exposure
to lead alone or lead and ethanol. The depletion of endogenous calcium and magnesium owing to lead or ethanol exposure was
also prevented by co-administration of lysine and zinc. |
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Keywords: | Lead intoxication ethanol lysine zinc calcium magnesium biochemical alterations rat |
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