Antidiabetes drug metformin is a donor of nitric oxide: EPR measurement of efficiency |
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| Authors: | V. A. Serezhenkov I. S. Kuznetsov T. I. Romantsova M. I. Kuznetsova A. F. Vanin |
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| Affiliation: | 1.Semenov Institute of Chemical Physics,Russian Academy of Sciences,Moscow,Russia;2.Setchenov First University of Medicine,Moscow,Russia;3.Scryabin Academy of Veterinary Medicine and Biotechnology,Moscow,Russia |
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| Abstract: | It is shown that metformin, which is a drug used for treatment of type 2 diabetes mellitus, is metabolized in vivo in the intestine and liver of mice with the release of nitric oxide. Subsequently the released nitric oxide forms paramagnetic mono- and dinitrosyl iron complexes which can be registered by EPR. It is suggested that nitric oxide is responsible for the multifarious therapeutic action of metformin such as lowering of blood glucose level, reduction of arterial hypertension, and other biological effects. |
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