Synthesis and biological activity of mustard derivatives of thymine |
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| Authors: | Hadj-Bouazza Amel Teste Karine Colombeau Ludovic Chaleix Vincent Zerrouki Rachida Kraemer Michel Sainte Catherine Odile |
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| Institution: | Laboratoire de Chimie des Substances Naturelles, Faculte des Sciences et Techniques Limoges, Universite de Limoges, France. |
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| Abstract: | The synthesis and biological activity of a novel DNA cross-linking antitumor agent is presented. The new alkylating agent significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line. |
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