Cytotoxicity of extractives from Taiwania cryptomerioides heartwood |
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Authors: | Chang S T Wang D S Wu C L Shiah S G Kuo Y H Chang C J |
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Institution: | Department of Forestry, National Taiwan University, Taipei. peter@ms.cc.ntu.edu.tw |
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Abstract: | The cytotoxicity of the dominant lignans and sesquiterpenoids from Taiwania (Taiwania cryptomerioides Hayata) was investigated. Three human tumor cells including A-549 lung carcinoma. MCF-7 breast adenocarcinoma and HT-29 colon adenocarcinoma were selected to illustrate the structure-cytotoxicity relationships of Taiwania's dominant compounds. Taiwanin A, taiwanin E and dimethylmatairesinol exhibited significant cytotoxicity against three human tumor cells. Among them, taiwanin A possesses the strongest cytotoxic activity. In addition, the morphology-based evaluation, flow cytometric analysis, and DNA fragmentation assays demonstrated that the tumor cell death induced by taiwanin A was due to apoptosis. |
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