Synthesis of 2'-deoxy-2'-fluoroguanyl-(3',5')-guanosine |
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| Authors: | Maruyama Tokumi Kozai Shigetada Nakamura Kazuo Irie Masachika |
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| Institution: | Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan. maruyama@ph.bunri-u.ac.jp |
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| Abstract: | The protected analogue of 2-amnio-6-chloropurine arabinoside (3b) was subjected to reaction with diethylaminosulfur trifluoride (DAST) and subsequently treated with NaOAc in Ac2O/AcOH to give N2, O3', O5'-triacetyl-2'-deoxy-2'-fluoroguanosine (5a). After deacetylation of the sugar moiety and protection of 5'-OH by a 4,4'-dimethoxytrityl group, this nucleoside component was converted to 2'-deoxy-2'-fluoroguanyl-(3',5')-guanosine (6c, GfpG). |
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