Effect of pH on citrinin and red pigments production by Monascus purpureus CCT3802 |
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Authors: | Sandra Fernanda Bilbao Orozco Beatriz Vahan Kilikian |
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Institution: | 1. Laboratório de Engenharia Bioquímica, Departamento de Engenharia Química, Escola Politécnica, Universidade de S?o Paulo, CP 61548, 05424-970, S?o Paulo, SP, Brazil
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Abstract: | The production of red pigments and citrinin by Monascus purpureus CCT3802 was investigated in submerged batch cultures performed in two phases: in the first phase, cells were grown on glucose,
at pH 4.5, 5.5 or 6.5; after glucose depletion, pH was adjusted, when necessary, to 4.5, 5.5, 6.5, 7.0, 8.0 or 8.5, for a
production phase. The highest total red pigments absorbance of 11.3 U was 16 times greater than the lowest absorbance and
was achieved with growth at pH 5.5, followed by production at pH 8.5, which causes an immediate reduction of the intra cellular
red pigments from 75% to 17% of the total absorbance. The lowest citrinin concentration, 5.5 mg L−1, was verified in the same culture while the highest concentration, 55 mg L−1, was verified in cultures entirely carried out at pH 5.5. An alkaline medium, besides promoting intra cellular red pigments
excretion, strongly represses citrinin synthesis. |
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Keywords: | Citrinin Monascus pH Red pigments Secondary metabolites |
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