Enzymatic methylations. II. In vitro inhibition of tRNA and protein methylation by nicotinamide and isonicotinic acid hydrazide: activation of a s-adenosylmethionine-splitting enzyme in rat liver

Recently, nicotinamide (1) and nicotinamide analogs (2) have been shown to inhibit tRNA methylation in vitro, and a competitive or “mixed type” inhibition has been postulated (1,2). In our preceeding paper we could exclude these inhibition mechanisms (3).