Pros and cons of fatty acids in bone biology |
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| Affiliation: | 1. Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;3. Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran;4. Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;1. Centre for Human Metabonomics, North–West University, Potchefstroom Campus, Potchefstroom, South Africa;2. Hypertension in Africa Research Team (HART), North–West University, Potchefstroom Campus, Potchefstroom, South Africa;1. Department of Immunology, Transplant Medicine and Internal Diseases, Transplantation Institute, Medical University of Warsaw, Warsaw, Poland;2. Department of Clinical Nursing, Medical University of Warsaw, Warsaw, Poland;3. Institute of Biochemistry and Biophysics Polish Academy of Sciences, Warsaw, Poland;4. Department of General and Transplantation Surgery, Transplantation Institute, Medical University of Warsaw, Warsaw, Poland;5. Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, Warsaw, Poland;6. Biology Department, Institute of Genetics and Biotechnology, Warsaw University, Warsaw, Poland;1. Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China;2. Shanghai Huangpu Maternity & Infant Health Hospital, Shanghai 200020, PR China;1. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia;2. Biomarkers & Research, Nordic Bioscience, Herlev, Denmark;3. Therapeutic Innovation Pole of Rheumatology, Institut de Recherches Servier, Suresnes, France;1. Department of Periodontics, Vydehi Institute of Dental Sciences and Research Centre, Whitefield, Bangalore, 560066, Karnataka, India;2. Department of Periodontics, DA Pandu Memorial R V Dental College and Hospital, J.P. Nagar, Bangalore, 560078, Karnataka, India |
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| Abstract: | Despite the growing interest in deciphering the causes and consequences of obesity-related disorders, the mechanisms linking fat intake to bone behaviour remain unclear. Since bone fractures are widely associated with increased morbidity and mortality, most notably in elderly and obese people, bone health has become a major social and economic issue. Consistently, public health system guidelines have encouraged low-fat diets in order to reduce associated complications. However, from a bone point of view, mechanisms linking fat intake to bone alteration remain quite controversial. Thus, after more than a decade of dedicated studies, this timely review offers a comprehensive overview of the relationships between bone and fatty acids. Using clinical evidences as a starting-point to more complex molecular elucidation, this work highlights the complexity of the system and reveals that bone alteration that cannot be solved simply by taking ω-3 pills. Fatty acid effects on bone metabolism can be both direct and indirect and require integrated investigations. Furthermore, even at the level of a single cell, one fatty acid is able to trigger several different independent pathways (receptors, metabolites…) which may all have a say in the final cellular metabolic response. |
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| Keywords: | Fatty acids Bone Nutrition Osteoporosis |
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