SARS-CoV-2 viral dynamics in non-human primates |
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Authors: | Antonio Gon alves,Pauline Maisonnasse,Flora Donati,M lanie Albert,Sylvie Behillil,Vanessa Contreras,Thibaut Naninck,Romain Marlin,Caroline Solas,Andres Pizzorno,Julien Lemaitre,Nidhal Kahlaoui,Olivier Terrier,Raphael Ho Tsong Fang,Vincent Enouf,Nathalie Dereuddre-Bosquet,Angela Brisebarre,Franck Touret,Catherine Chapon,Bruno Hoen,Bruno Lina,Manuel Rosa Calatrava,Xavier de Lamballerie,France Mentr ,Roger Le Grand,Sylvie van der Werf,J r mie Guedj |
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Abstract: | Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large burst size (>104 virus) and a within-host reproductive basic number of approximately 6 and 4 in nasopharyngeal and tracheal compartment, respectively. After peak viral load, infected cells were rapidly lost with a half-life of 9 hours, with no significant association between cytokine elevation and clearance, leading to a median time to viral clearance of 10 days, consistent with observations in mild human infections. Given these parameter estimates, we predict that a prophylactic treatment blocking 90% of viral production or viral infection could prevent viral growth. In conclusion, our results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments. |
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