The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1 |
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Authors: | Setogawa Takeshi Shinozaki-Yabana Satoko Masuda Takahisa Matsuura Ken Akiyama Tetsu |
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Affiliation: | Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. |
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Abstract: | The LKB1/STK11 serine/threonine kinase is mutated in Peutz-Jeghers syndrome and various sporadic cancers such as lung adenocarcinoma. We show here that LKB1 forms a complex with LMO4, GATA-6, and Ldb1, and enhances GATA-mediated transactivation in a kinase-dependent manner. We further demonstrate that LKB1 has the potential to induce p21 expression in collaboration with LMO4, GATA-6, and Ldb1 through the p53-independent mechanism. Our findings suggest that LKB1 regulates GATA-mediated gene expression and that this activity of LKB1 may be important for its tumor suppressor function. |
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Keywords: | Peutz-Jeghers syndrome Tumor suppressor LKB1 LMO4 GATA-6 Ldb1 p21 |
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