Promoter characterization and expression of the gene coding for the human GM2 activator protein |
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| Authors: | Beccari T Balducci C Aisa M C Della Fazia M A Servillo G Orlacchio A |
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| Institution: | (1) Dipartimento di Scienze Biochimiche e Biotecnologie Molecolari, Università degli Studi di Perugia, Via del Giochetto, 06126 Perugia, Italy |
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| Abstract: | Type 2 diabetes (or non-insulin dependent diabetes mellitus, NIDDM) is a common metabolic disease in man. The Goto–Kakizaki (GK) rat has been designed as a NIDDM model. Previous studies with this strain have shown differences at the mitochondrial level. The mitochondrial permeability transition (MPT) is a widely studied phenomenon but yet poorly understood, that leads to mitochondrial dysfunction and cell death. The aim of this work was to compare the differences in susceptibility of induction of the MPT with calcium phosphate in GK and Wistar rats. Our results show that heart mitochondria from GK rats are less susceptible to the induction of MPT, and show a larger calcium accumulation before the overall loss of mitochondrial impermeability. |
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| Keywords: | GM2 activator protein GM2 ganglioside gene expression promoter |
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