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Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes |
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| Authors: | Chen Ping Caldwell Charles G Mathvink Robert J Leiting Barbara Marsilio Frank Patel Reshma A Wu Joseph K He Huaibing Lyons Kathryn A Thornberry Nancy A Weber Ann E |
| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. ping_chen@merck.com |
| Abstract: | A series of substituted imidazopiperidine amides has been prepared and evaluated for inhibition of dipeptidyl peptidase IV (DPP-4). Substitution at the 1- and 3-positions produced increased selectivity for DPP-4 relative to DPP-8 and DPP-9. Compounds in this series had IC(50) values as low as 5.8 nM for inhibition of DPP-4. |
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