Vasoactive intestinal polypeptide and endometrial blood flow in the goat |
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Authors: | B. Ottesen N. Einer-Jensen A.M. Carter |
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Affiliation: | 1. Department of Physiology, University of Odense, Campusvej 55, DK-5230 Odense Denmark;1. Department of Medical Physiology B, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen Denmark |
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Abstract: | Endometrial blood flow was measured in seven goats twice before, once during, and twice after the close intra-arterial infusion of 300 pmol/min of vasoactive intestinal polypeptide (VIP). A saline solution of 85krypton was injected intra-arterially and local blood flow calculated from the disappearance rate of the isotope from tissue surrounding a miniature Geiger-Müller probe in the uterine lumen. Initial blood flows (median and range) in animals pretreated with oestradiol-17β (N = 4) or with a regimen of oestradiol-17β and progesterone (N = 3), respectively, were 0.21 (0.11–0.35) and 0.20 (0.06–0.27) ml min?1 g?1. No significant change in endometrial blood flow occurred during or after the infusion of VIP, although the dose was sufficient to increase heart rate from 2.14 ± 0.15 to 2.32 ± 0.16 Hz (P < 0.001). The results indicate that VIP, in a dose known to increase myometrial blood flow in goats, is unable to evoke vasodilatation in the endometrium of this species. Since there is a corresponding variation in the density of nerve fibers containing VIP, it is suggested that VIP may play a role in regulating the partition of uterine blood flow in goats. |
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