Evolution of the IL17 receptor family in chordates: a new subfamily IL17REL |
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Authors: | Baojun Wu Meng Jin Yi Zhang Tiandi Wei Zengliang Bai |
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Institution: | (1) Laboratory of Developmental Immunology, School of Life Science, Shandong University, Jinan, 250100, China;(2) Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Jinan, 250100, China;(3) Department of Plastic Surgery, Jinan Central Hospital of Shandong University, Jinan, 250013, China;(4) State Key Laboratory of Microbiological Technology, School of Life Science, Shandong University, Jinan, 250100, China; |
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Abstract: | The human interleukin 17 receptor (IL17R) family plays a critical role in inflammatory responses and contributes to the pathology
of many autoimmune diseases. So far, five members, IL17RA to IL17RE, have been identified. Recently, some IL17R genes have
been identified in non-mammalian species, such as zebrafish IL17RD; however, there are no reports on the evolutionary history
of this complex gene family through comparative phylogenetic approaches. Here, we concentrated on the IL17R evolution in chordates.
There are two IL17Rs in the genome of the basal chordate amphioxus: IL17RA and IL17RD. After two rounds of whole genome duplications,
these two IL17R genes expanded into five early vertebrate IL17R genes, IL17RA to IL17RE. IL17RA and IL17RD are found in most
vertebrates, whereas the other three, IL17RB, ILR17RC, and IL17RE, underwent some loss in vertebrates during evolution. Our
sequence and structure analyses reveal functional similarities and distinctions between the different IL17Rs. Based on similarity
searches for IL17R-like proteins within chordate sequences, a group of IL17RE-like (IL17REL) proteins were identified from
mammalians to lower vertebrates. In silico and expression analyses on the novel IL17RELs showed that this group of receptors is highly conserved across species, indicating
that IL17REL may represent a unique subfamily of IL17Rs. |
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