Putative alternative functions of human stefin B (cystatin B): binding to amyloid‐beta,membranes, and copper |
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Abstract: | We describe studies performed thus far on stefin B from the family of cystatins as a model protein for folding and amyloid fibril formation studies. We also briefly mention our studies on aggregation of some of the missense EPM1 mutants of stefin B in cells, which mimic additional pathological traits (gain in toxic function) in selected patients with EPM1 disease. We collected data on the reported interactors of stefin B and discuss several hypotheses of possible cytosolic alternative functions. |
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Keywords: | amyloid chaperone cystatins membrane binding oligomers oxidative stress protein aggregation protein folding |
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