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The amino acid sequences of homologous hydroxyproline-containing myotoxins from the marine snail Conus geographus venom
Authors:S Sato  H Nakamura  Y Ohizumi  J Kobayashi  Y Hirata
Affiliation:1. Mitsubishi-Kasei Institute of Life Sciences, 11 Minamiooya, Machida-shi, Tokyo 194, Japan;2. Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468, Japan
Abstract:Two homologous toxic peptides containing hydroxyproline from the venom of the marine snail Conus geographus have been sequenced.Geographutoxin I:
/></figure>Geographutoxin II: Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Arg-Lys-Cys-Lys-Asp-Arg-Arg-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH<sub>2</sub>These peptides inhibit the contractile response of directly stimulated mouse diaphragm.</td>
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Keywords:Toxic peptide  Geographutoxin I and II  Amino acid sequence  Hydroxyproline
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