NMR studies of P-450 model systems: new structural probes for sulfur-containing hemoproteins. |
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| Authors: | A P Berzinis T G Traylor |
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| Affiliation: | Department of Chemistry, University of California, San Diego La Jolla, California 92093 USA |
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| Abstract: | A simple model for ferrous cytochrome P-450 has been investigated by proton and carbon-13 Fourier transform NMR. In the proton spectrum of the β-phenethyl mercaptan-protoheme-CO complex, the protons α and β to mercaptide sulfur are observed 2.62 and 0.62 ppm upfield of tetramethylsilane. The 13CO spectra show characteristic shifts at 204.7 and 197.0 δ for neutral and deprotonated mercaptan complexes, respectively. |
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| Keywords: | To whom reprint requests should be addressed. |
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