| 哺乳动物中丙酮酸脱氢酶复合体的活性调节 |
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| 引用本文： | 李凤艳,刘晓晴. 哺乳动物中丙酮酸脱氢酶复合体的活性调节[J]. 生物技术通报, 2006, 0(1): 9-12 |
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| 作者姓名： | 李凤艳 刘晓晴 |
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| 作者单位： | 首都师范大学生命科学学院,北京,100037 |
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| 摘 要： | 高等生物的一个重要代谢调控机制是通过对酶的磷酸化和去磷酸化来进行的,哺乳动物的丙酮酸脱氢酶复合体(pyruvate dehydrogenase complex,PDHc)也是如此。PDHc的活性的调节主要是通过对其E1(pyru-vate dehydrogenase,PDH)的磷酸化和去磷酸化来实现的。当机体主要靠储存的脂肪生存而所存的葡萄糖仅供大脑和神经组织等只能依靠葡萄糖来提供能量的器官使用的时候,即葡萄糖缺乏时,就需要抑制PDHc的活性。主要探讨了哺乳动物在特定器官中和特定的一些生理条件下,PDHc活性改变的一些规律。
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| 关 键 词： | 丙酮酸脱氢酶复合体 丙酮酸脱氢酶激酶 活性调节 磷酸化 去磷酸化 |
| 收稿时间： | 2005-11-14 |
| 修稿时间： | 2005-11-14 |
Regulation of the Activity of the Mammalian Pyruvate Dehydrogenase Complex |
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| Li Fengyan,liu Xiaoqing. Regulation of the Activity of the Mammalian Pyruvate Dehydrogenase Complex[J]. Biotechnology Bulletin, 2006, 0(1): 9-12 |
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| Authors: | Li Fengyan liu Xiaoqing |
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| Affiliation: | College of Life Science, Capital Normal University, Beijing 100037 |
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| Abstract: | Through the phosphorylation and dephosphorylation of the E1(pyruvate dehydrogenase,PDH) of the PDHc,the activity of the Mammalian pyruvate dehydrogenase complex has been regu-lated.When the body should be living primarily off its stored fat and thereby conserve ingglucose for use by the brain,the rate of pyruvate decarboxylation has to be carefully contr-olled to match the overall energy need of the body.In this paper,Mechanisms have there-fore discussed to inactivate the pyruvate dehydrogenase complex when glucose becomes scarce. |
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| Keywords: | Pyruvate dehydrogenase complex Pyruvate dehydrogenase kinase Regulation of the activity Phosphorylation Dephosphorylation |
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