ABC Proteins of Leishmania |
| |
Authors: | Danielle Légaré Stéphane Cayer Ajay K Singh Dave Richard Barbara Papadopoulou Marc Ouellette |
| |
Institution: | Centre de Recherche en Infectiologie du Centre de Recherche du CHUL, Québec, Canada. |
| |
Abstract: | ABC proteins were first characterized in the protozoan parasite Leishmania while studying mechanisms of drug resistance. PGPA is involved in resistance to arsenite and antimonite and it most likely confers resistance by sequestering metal–thiol conjugates into an intracellular vesicle. PGPA is part of gene family with at least four more members which are in search of a function. Leishmania also contains a P-glycoprotein, homologous to the mammalian MDR1, that is involved in multidrug resistance. The ongoing genome project of Leishmania has pinpointed several novel ABC transporters and experiments are carried out to study the function of the ABC proteins in drug resistance and in host–pathogen interactions. |
| |
Keywords: | Leishmania ABC proteins efflux drug resistance glutathione trypanothione sequestration |
本文献已被 SpringerLink 等数据库收录! |