Levels of the bcl-2 protein, fibronectin and α5β1 fibronectin receptor in HIV-1-infected patients with Kaposi’s sarcoma |
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| Authors: | Donato Torre Claudia Zeroli Roberto Martegani Agostino Pugliese Cristina Basilico Filippo Speranza |
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| Affiliation: | a Division of Infectious Diseases, Regional Hospital, Viale Borri 57, 21100 Varese, Italy;b Division of Infectious Diseases, General Hospital, Busto Arsizio, Italy;c Institute of Infectious Diseases, Amedeo di Savoia Hospital, University of Turin, Turin, Italy |
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| Abstract: | Kaposi's sarcoma (KS) is an angioproliferative disease characterized by proliferation of neoplastic cells (spindle cells) mixed with endothelial and inflammatory cells. In this study we evaluated the role of the adhesive glycoprotein, fibronectin (FN) and its receptor α5β1 (FNR), and the proto-oncogene bcl-2, an anti-apoptotic protein. Significantly decreased serum levels of FN were noted in HIV-1-infected patients with KS, whereas serum levels of FNR were significantly increased in the same patients. Furthermore, increased FNR expression was observed on CD4 cells from KS patients. Serum levels of bcl-2 protein were significantly decreased in asymptomatic seropositive patients, whereas HIV-1-infected patients with KS showed increased serum levels of bcl-2. These results provide further information about interaction between integrins and the extracellular matrix and bcl-2 protein that can support cell survival either of neoplastic cells or endothelial and inflammatory cells. |
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| Keywords: | Kaposi’ s sarcoma fibronectin receptor bcl-2 HIV-1 infection |
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